VHL Polyclonal Antibody
簡(jiǎn)要描述：VHL Polyclonal Antibody宿主: Polyclonal, Rabbit,IgG反應(yīng)性: Human;Mouse;Rat應(yīng)用: IHC;IF;ELISA
產(chǎn)品型號(hào)： YP-Ab-00548
所屬分類：多克隆抗體
更新時(shí)間：2024-11-01
詳細(xì)說明：
VHL Polyclonal Antibody
抗體，也叫免疫球蛋白（Ig），是一種能特異性結(jié)合抗原的糖蛋白，而抗原是在易感染動(dòng)物體內(nèi)引發(fā)抗體產(chǎn)生的物質(zhì)。在體內(nèi)，抗體是由于外源性分子的侵襲而產(chǎn)生的?？贵w以一個(gè)或者多個(gè)Y字形單體存在，每個(gè)Y字形單體由4條多肽鏈組成，包含兩條相同的重鏈和兩條相同的輕鏈。輕鏈和重鏈?zhǔn)歉鶕?jù)它們的分子量大小來命名的。Y字形結(jié)構(gòu)的頂端是可變區(qū)，為抗原結(jié)合部位。任何一個(gè)抗體的輕鏈都可以分為κ或λ型（基于小分子多肽結(jié)構(gòu)上的差異），每一個(gè)抗體的重鏈則決定了它的類或型。
產(chǎn)品詳情
VHL Polyclonal Antibody detects endogenous levels of VHL protein.
免疫原詳細(xì)信息
The antiserum was produced against synthesized peptide derived from human VHL. AA range:34-83
相關(guān)試劑
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
背景
von Hippel-Lindau tumor suppressor(VHL) Homo sapiens Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
天津俊達(dá)生物科技有限公司，是從事實(shí)驗(yàn)室耗材銷售的現(xiàn)代化生物科技企業(yè)，公司本著“誠(chéng)信為本，互利共贏"的核心價(jià)值觀，秉承“以市場(chǎng)為導(dǎo)向，提供服務(wù)"的宗旨為各大院校、科研單位、第三方實(shí)驗(yàn)室檢測(cè)機(jī)構(gòu)等提供的產(chǎn)品和服務(wù)。目前公司主要經(jīng)營(yíng)分子生物學(xué)、細(xì)胞生物學(xué)、免疫學(xué)等生物學(xué)產(chǎn)品，多種實(shí)驗(yàn)室耗材 歡迎垂詢！
備注：圖片僅供參考。僅供科研，不可用于臨床。
